Research advances in the molecular mechanisms underlying pronuclear formation and disappearance in mammals
10.3760/cma.j.cn101441-20250206-00047
- VernacularTitle:哺乳动物原核形成和消失的分子机制研究进展
- Author:
Chaoying WANG
1
;
Guidong YAO
1
Author Information
1. 郑州大学第一附属医院生殖医学中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Oocytes;
Fertilization;
Embryonic development;
Pronuclear formation;
Pronuclear disappearance
- From:
Chinese Journal of Reproduction and Contraception
2025;45(8):856-860
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian fertilization is a highly complex and finely regulated process that involves sperm-oocyte fusion and subsequent cell fate decisions. This article reviews the molecular mechanisms underlying pronucleus formation and disappearance during mammalian fertilization, with particular focus on the key molecules and regulatory mechanisms involved in these processes. It further discusses how failures in pronucleus formation and disappearance may lead to abnormal embryonic development and various infertility issues, along with potential solutions to address these abnormalities. The aim is to provide a theoretical foundation for understanding the molecular mechanisms that contribute to abnormal pronucleus formation and disappearance in the context of reproductive biology and assisted reproductive technology, while also highlighting potential directions for future research.
