Progress in study of effect of valproic acid on male reproductive function in epileptic adults

VernacularTitle:丙戊酸对癫痫男性生殖功能影响的研究进展
Author: Kejing LI ¹ ; Pei LI ; Zheng YIN ; Xijun LI ; Xin LI
Author Information

1. 青海大学研究生院，西宁　810007
Publication Type:Journal Article
Keywords: Valproic acid; Epilepsy; Metabolic syndrome; Reproduction; Men
From: Chinese Journal of Reproduction and Contraception 2025;45(8):851-855
CountryChina
Language:Chinese
Abstract: Valproic acid (VPA) is a traditional broad-spectrum antiepileptic drug, but long-term use of VPA will increase the risk of adverse drug reactions, with metabolic syndrome being the most common and often leading to infertility in men. Therefore, it is crucial to explore the relationship between epilepsy, VPA, metabolic syndrome and reproduction, the underlying pathogenesis, risk factors, and therapeutic measures. This exploration is essential for preventing adverse drug reactions and for guiding safe and rational use of drugs in clinical practice. This article summarizes the incidence of drug-induced metabolic syndrome and infertility in men with epilepsy who are treated with oral VPA, aiming to provide new research insights for optimizing treatment and reducing drug side effects.