Analysis of human papillomavirus infection types and clinical characteristics in menopausal patients with high-grade cervical intraepithelial lesions or cervical cancer
10.3760/cma.j.cn341190-20240506-00518
- VernacularTitle:绝经期宫颈高级别上皮内病变或宫颈癌患者HPV感染及临床特点分析
- Author:
Shumin ZHANG
1
;
Yixuan FU
1
;
Yalan QI
1
Author Information
1. 徐州医科大学附属宿迁医院 南京鼓楼医院集团宿迁医院妇产科，宿迁 223800
- Publication Type:Journal Article
- Keywords:
Squamous intraepithelial lesions of the cervix;
Human papillomavirus 16;
Uterine cervical neoplasms;
Menopause;
Colposcopy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(12):1773-1777
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze human papillomavirus (HPV) infection types and clinical characteristics in postmenopausal patients with high-grade squamous intraepithelial lesion or cervical cancer.Methods:The clinical data of 475 patients diagnosed with high-grade squamous intraepithelial lesions or cervical cancer, pathologically confirmed by colposcopic biopsy, were retrospectively analyzed. These patients received treatment at The Affiliated Suqian Hospital of Xuzhou Medical University (Nanjing Drum Tower Hospital Group Suqian Hospital) between September 2021 and September 2022. The patients were divided into two groups based on their menopausal status: the menopausal group and the non-menopausal group. The clinical data and the types of high-risk HPV infections were compared between the two groups.Results:Among the 475 patients, there were 142 in the menopausal group, with an average age of (57.63 ± 6.23) years, and 333 in the non-menopausal group, with an average age of (36.79 ± 6.85) years. The proportion of patients with no prior history of cervical cancer screening and those who sought medical attention due to clinical symptoms was higher in the menopausal group than in the non-menopausal group [23.2% (33/142) vs. 5.4% (18/333), χ2 = 33.03, P < 0.05]. Among the 475 patients, 347 underwent HPV typing tests, with the top five HPV types identified as 16, 52, 58, 33, and 18. The positive rate of HPV 16 was lower in the menopausal group compared with the non-menopausal group [43.8% (32/73) vs. 61.3% (168/274), χ2 = 7.53, P < 0.05], while the positive rate of HPV 52 was higher in the menopausal group [28.8% (21/73) vs. 13.5% (37/274), χ2 = 9.64, P < 0.05]. The proportion of multiple infections was also higher in the menopausal group compared with the non-menopausal group [47.9% (35/73) vs. 31.8% (87/274), χ2 = 6.63, P < 0.05]. The proportion of patients with type 3 transformation zone in the menopausal group was higher [63.4% (90/142) vs. 23.4% (78/333), χ2 = 69.52, P < 0.05], as was the proportion of cervical canal curettage [59.9% (85/142) vs. 33.6% (112/333), χ2 = 28.20, P < 0.05] compared with the non-menopausal group. The proportion of patients with cervical cancer in the menopausal group was higher than in the non-menopausal group [35.2% (50/142) vs. 8.7% (29/333), χ2 = 50.42, P < 0.05]. The proportion of patients with cervical cancer at stage ≥ IB in the menopausal group was 90% (45/50). Conclusion:In patients with high-grade squamous intraepithelial lesions or cervical cancer, HPV 16 is the most common type. In the menopausal group, there is a high proportion of patients who are positive for HPV 52, an elevated rate of multiple infections, a low cervical screening rate, and a high incidence of cancer, with many patients presenting at late stages.
