Level and clinical significance of CD4+CD25+CD127low regulatory T cell in patients with diffuse large B-cell lymphoma
10.3969/j.issn.1000-484X.2025.05.014
- VernacularTitle:CD4+CD25+CD127low调节性T细胞在弥漫大B细胞淋巴瘤患者中的水平及其临床意义
- Author:
Keke HUANG
1
;
Jiyu WANG
1
;
Huiping WANG
1
;
Zhimin ZHAI
1
Author Information
1. 安徽医科大学第二附属医院血液内科,合肥 230601
- Publication Type:Journal Article
- Keywords:
Regulatory T cells;
Diffuse large B-cell lymphoma;
Prognosis
- From:
Chinese Journal of Immunology
2025;41(5):1102-1107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the level of regulatory T cell(Treg)in peripheral blood of diffuse large B-cell lymphoma(DLBCL)patients at initial diagnosis,and its value in the evaluation of efficacy and prognosis.Methods:A total of 72 newly diagnosed DLBCL patients admitted to the Second Affiliated Hospital of Anhui Medical University from January 2018 to February 2022 were selected as research objects,and 17 healthy volunteers were taken as the control group.The level of CD4+CD25+CD127lowTreg in peripheral blood of patients was detected by flow cytometry,and a comparative analysis was conducted in conjunction with the clinical characteristics of patients.Results:The percentage of Treg in peripheral blood before treatment was correlated with Ann Arbor stage,IPI score,ECOG score and hemoglobin(HB).The levels of Treg in peripheral blood at initial diagnosis were significantly lower than that of healthy con-trols(3.85±0.22 vs 5.15±0.31,P=0.007).DLBCL patients were divided into high Treg group and low Treg group according to the me-dian percentage of CD4+CD25+CD127lowTreg in peripheral blood to CD4+T cells at initial diagnosis,the total effective rate of high Treg group was significantly higher than that of low Treg group(P=0.035).ECOG score(P=0.040)and low level of Treg before treatment(P=0.014)were independent risk factors for progression-free survival(PFS)in DLBCL patients.Having B symptom(P=0.028),ECOG score≥2(P=0.041)and low level of Treg before treatment(P=0.036)were independent risk factors for OS.PFS(P=0.020)and OS(P=0.036)in low Treg group were significantly lower than those in high Treg group.Conclusion:The low percentage of CD4+CD25+CD127lowTreg in peripheral blood of newly diagnosed DLBCL patients indicates a poor prognosis.
