Association of atopic dermatitis with ankylosing spondylitis:A two-sample Mendelian randomized study
10.3969/j.issn.1000-484X.2025.05.006
- VernacularTitle:特应性皮炎与强直性脊柱炎的关联:双样本孟德尔随机化研究
- Author:
Mingjing WEI
1
;
Zhengchao SHAO
1
;
Haoyue WAN
1
;
Yiheng WANG
1
;
Wenqi CHEN
1
Author Information
1. 南京医科大学附属南京医院/南京市第一医院皮肤科,南京 210000
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
Atopic dermatitis;
Ankylosing spondylitis;
Causal inference
- From:
Chinese Journal of Immunology
2025;41(5):1055-1059
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether there is a causal relationship between atopic dermatitis(AD)and ankylosing spondylitis(AS).Methods:Genetic data of AD and AS were extracted from genome-wide association studies(GWAS)by Mendelian randomization(MR),and inverse variance-weighted(IVW)analysis was used as main analysis,supplemented by weighted median,MR-Egger,weighted mode,etc,and verified by a series of sensitivity analyses.Results:IVW analysis of AD by AS:OR=1.015,95％CI:1.005～1.025,P=0.004.IVW analysis of AD for AS:OR=1.001,95％CI:1.000～1.002,P=0.120.Conclusion:AS has a statisti-cally small causal relationship on AD,and AD has no causal effect on AS.
