Research progress on the mechanism of endometrial microenvironment in adverse pregnancy outcomes
10.3760/cma.j.cn101441-20250117-00026
- VernacularTitle:子宫内膜微环境在不良妊娠结局中作用机制的研究进展
- Author:
Yue GAO
1
;
Zheng GONG
1
;
Jumei SHI
1
;
Saihua MA
1
;
Cong WANG
1
;
Tian XIA
1
Author Information
1. 天津中医药大学第一附属医院生殖科，天津 300381
- Publication Type:Journal Article
- Keywords:
Pre-eclampsia;
Intrauterine growth restriction;
Recurrent pregnancy losses;
Adverse pregnancy outcomes;
Endometrial microenvironment
- From:
Chinese Journal of Reproduction and Contraception
2025;45(7):741-745
- CountryChina
- Language:Chinese
-
Abstract:
Adverse pregnancy outcome (APO) refers to any pregnancy outcome other than a normal live birth, mainly including preeclampsia, fetal growth restriction, recurrent pregnancy loss, etc., which seriously threaten the health of both the mother and the fetus. Most APOs originate from abnormal uterine endometrial microenvironment before pregnancy. Once a woman confirms pregnancy, intervening in the uterine endometrium at this stage is often too late. The uterine endometrium, as a key site for embryo implantation and development, its abnormal microenvironment can lead to APO. Therefore, in-depth exploration of the relationship between the pre-pregnancy uterine endometrial microenvironment and APO is helpful for clarifying the mechanism of APO occurrence and providing key ideas and methods for early prevention and treatment. This article reviews the latest research on the mechanism of action between uterine endometrial microenvironment and APO, systematically summarizing the research progress and main conclusions in this field from several aspects such as immune imbalance, inflammatory response, abnormal energy metabolism, and senescence of uterine endometrial stromal cells.
