Progress in the mechanism and clinical application of platelet-rich plasma in the treatment of intrauterine adhesions
10.3760/cma.j.cn101441-20250124-00036
- VernacularTitle:富血小板血浆治疗宫腔粘连的机制与临床应用进展
- Author:
Jijing XU
1
;
Xiaoyan PAN
1
Author Information
1. 吉林医药学院生殖医学研究中心，吉林 132013
- Publication Type:Journal Article
- Keywords:
Platelet-rich plasma;
Intrauterine adhesions;
Growth factor;
Tissue repair
- From:
Chinese Journal of Reproduction and Contraception
2025;45(7):735-740
- CountryChina
- Language:Chinese
-
Abstract:
Intrauterine adhesions are adhesions of the uterine wall caused by damage to the basal layer of the endometrium, which will affect women's menstruation and fertility. At present, the effect of surgery and drug treatment is not ideal, and it is easy to relapse. Platelet-rich plasma (PRP) is a kind of plasma with high concentration of platelets obtained by centrifuging autologous blood, containing a variety of bioactive factors (platelet-derived growth factor, transforming growth factor-β, vascular endothelial growth factor, insulin-like growth factor 1, etc.), which can significantly promote cell proliferation and differentiation, angiogenesis, relieve inflammation and prevent infection, reduce fibrosis and be used as biological scaffold in the treatment of uterine adhesion. It can significantly improve endometrial morphology, reduce fibrosis and improve fertility. In view of the advantages of PRP in the treatment of intrauterine adhesions, this paper will discuss the characteristics, mechanism and application of PRP in the treatment of intrauterine adhesions, so as to further understand the important role of PRP in the treatment of intrauterine adhesions and lay a foundation for its clinical application.
