Research progress on the relationship between ovarian microenvironment and polycystic ovary syndrome
10.3760/cma.j.cn101441-20241120-00431
- VernacularTitle:卵巢微环境与多囊卵巢综合征关系的研究进展
- Author:
Jia JIA
1
;
Xiaoli ZHAO
1
;
Linling WU
1
;
Shiman CHENG
1
Author Information
1. 天津中医药大学第一附属医院生殖医学科 国家中医针灸临床医学研究中心，天津 300381
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Ovarian microenvironment;
Follicular development disorder
- From:
Chinese Journal of Reproduction and Contraception
2025;45(4):409-413
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women that is a leading cause of infertility. Follicular development disorder, as the main cause of oligoovulation, is the key factor affecting the fertility of PCOS patients. Among them, the disorder of the ovarian microenvironment is an important inducement for follicular development disorder. Emerging research highlights that the ovarian microenvironment plays a sophisticated role in follicular development and maturation through various mechanisms, including the cellular constituents within the ovary, the extracellular matrix's structural support, adequate vascular supply, and the regulation of hormonal and growth factor signaling. These factors collectively ensure the normal growth and ovulation of follicles, thereby safeguarding female reproductive health. In women with PCOS, however, the ovarian microenvironment is compromised, leading to excessive extracellular matrix deposition and fibrosis, abnormalities in vascular architecture and function, immune-inflammatory reactions, and metabolic disturbances. These anomalies collectively hinder follicular growth and development, resulting in ovulation disorders. This comprehensive review will delve into the intricacies of these disruptions and their implications for fertility in PCOS patients.
