Association between Chromium Exposure and Liver Injury Indicators in Diabetes Patients:Conditional Process Mediation Model
10.11783/j.issn.1002－3674.2025.02.009
- VernacularTitle:铬暴露与糖尿病肝损伤指标关联研究:条件过程模型
- Author:
Xiao LU
1
;
Hui YANG
;
Miao YUAN
Author Information
1. 山西医科大学卫生统计教研室(030001)
- Publication Type:Journal Article
- Keywords:
Diabetes;
Liver injury;
Chromium;
Total protein;
Conditional process model
- From:
Chinese Journal of Health Statistics
2025;42(2):204-208,213
- CountryChina
- Language:Chinese
-
Abstract:
Objective The exploration of the mediating effect of chromium exposure on the blood routine indicators of diabetes patients is limited.This study aims to explore the possible mediating path by using the conditional process mediation model.Methods The study was based on the results of cross－sectional data in 2018 in the environmental chromium exposure and population health research database provided by the Institute of Basic Medicine of the Chinese Academy of Medical Sciences.A total of 436 patients were selected in this study according to the emission criteria.SPSS 24.0 and SPSS plug－in Process are selected and applied to the construction of demographic data and intermediary model respectively.Result In the conditional process analysis with total bilirubin as the regulatory variable,total bilirubin had a positive regulatory effect on the path of urine chromium→total protein and urine chromium → LDL.In the conditional process analysis with blood glucose as the regulatory variable,blood glucose had a positive regulatory effect on urine chromium → total protein and LDL→ total protein pathways.In the conditional process analysis using both blood glucose and total bilirubin as regulatory variables,blood glucose and total bilirubin had a positive regulatory effect on the LDL→ total protein pathway.Conclusion Diabetes patients with chromium exposure history should focus on the effects of LDL,total bilirubin and blood glucose levels on TP,which is conducive to preventing liver injury in diabetes patients and improving their disease prognosis and quality of life.
