Research progress on the impact of obesity on oocyte quality and early embryo development
10.3760/cma.j.cn101441-20250213-00061
- VernacularTitle:肥胖对卵子质量和早期胚胎发育影响的研究进展
- Author:
Jie ZHANG
1
;
Haixing YI
;
Huanhuan JIANG
Author Information
1. 安徽医科大学第一附属医院妇产科，合肥 230032
- Publication Type:Journal Article
- Keywords:
Obesity;
Reproductive technology, assisted;
Pregnancy complications;
Oocyte quality;
Early embryonic development
- From:
Chinese Journal of Reproduction and Contraception
2025;45(7):751-756
- CountryChina
- Language:Chinese
-
Abstract:
This paper comprehensively discusses the impact of obesity on female fertility, oocyte quality, early embryonic development, and assisted reproductive technology (ART), and evaluates the relationship between obesity and pregnancy complications, proposing corresponding prevention and treatment strategies. Studies have shown that obesity adversely affects oocyte quality through chronic inflammation, oxidative stress, and disruption of metabolic pathways, including meiotic defects, mitochondrial dysfunction, and epigenetic alterations. Obesity also affects early embryonic development, potentially leading to placental dysfunction and restricted fetal growth. In the field of ART, obese women face more challenges, such as increased risk of gestational diabetes and decreased success rates of in vitro fertilization. Additionally, obesity is associated with an increased risk of various pregnancy complications, including hypertensive disorders of pregnancy, gestational diabetes, preterm birth, and cesarean section. This paper emphasizes the importance of preconception and prenatal weight management and proposes strategies to improve the fertility of obese women through lifestyle changes, pharmacological treatment, and surgical intervention. Ultimately, this thesis provides personalized recommendations for the reproductive health of obese women to improve fertility and pregnancy outcomes, ensuring the health status of both mother and child.
