Potential of prostaglandin D2 and its metabolites in tumor immunotherapy:mechanisms and applications based on animal models
10.3969/j.issn.1005-4847.2025.03.013
- VernacularTitle:前列腺素D2及其代谢物在肿瘤免疫治疗中的潜力:基于动物模型的机制与应用
- Author:
Hongping LUO
1
;
Dengxu TAN
;
Qingling AN
;
Bing BAI
;
Yanying ZHANG
;
Changhong SHI
Author Information
1. 甘肃中医药大学,兰州 730000;空军军医大学实验动物中心,西安 710032
- Publication Type:Journal Article
- Keywords:
prostaglandin D2;
prostaglandin D2 synthase;
tumor;
microenvironment;
immunotherapy
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(3):449-456
- CountryChina
- Language:Chinese
-
Abstract:
Prostaglandin D2(PGD2)is a biologically active substance with important roles in a variety of physiological and pathological processes.PGD2 exerts its biological functions mainly through prostaglandin D2 synthase(PGDS),which is closely related to inflammation and immune regulation.Recent studies have found that PGD2 and its synthase,PGDS,are able to directly inhibit tumor cell proliferation,induce apoptosis,suppress migration and invasion,and further regulate the tumor immune microenvironment to affect the immunotherapy of tumors,demonstrating good tumor therapeutic potential.In this paper,we review the biological properties of PGD2 and its synthase,focusing on its role in the immunotherapy of tumor models.We explore the immunotherapeutic efficacy of PGD2 and its synthase,and their roles in promoting immune cell infiltration in the tumor microenvironment,and discuss their potential as new targets for tumor therapy.
