Impact of pathological aging of the endometrium on embryo implantation
10.3760/cma.j.cn101441-20241127-00445
- VernacularTitle:子宫内膜病理性衰老对胚胎植入的影响
- Author:
Yingying JIA
1
;
Xiaoli ZHAO
1
;
Jiaqi XU
1
;
Nan JIANG
1
;
Zimu WEN
1
;
Kaixi LI
1
;
Tian XIA
1
Author Information
1. 天津中医药大学第一附属医院生殖中心 国家中医针灸临床医学研究中心，天津 300381
- Publication Type:Journal Article
- Keywords:
Embryo implantation;
Reproductive disorders;
Endometrial receptivity;
Endometrial aging
- From:
Chinese Journal of Reproduction and Contraception
2025;45(5):462-467
- CountryChina
- Language:Chinese
-
Abstract:
Decreased endometrial receptivity is a critical factor contributing to the decline in fertility among women of advanced age. With the increase of age, the endometrium exhibits diminished hormonal responsiveness, a phenomenon known as inflammaging, and an imbalance in immune cell populations. These changes impede the processes of endometrial epithelial-mesenchymal transition and decidualization, thereby negatively impacting embryo implantation and reducing overall fertility potential. Furthermore, adverse lifestyle choices, exposure to environmental factors, inflammatory conditions, and repeated interventions within the uterine cavity can result in pathological aging of the endometrium that does not align with its chronological age. This misalignment may be associated with the emergence of various reproductive disorders, even in younger women. This paper seeks to investigate the relationship between pathological aging of the endometrium and reproductive disorders, particularly in the context of embryo implantation, with the aim of providing new insights into the pathogenesis, clinical diagnosis, and treatment of reproductive disorders.
