Research progress on the effect of tumor necrosis factor-α on the pathogenesis and treatment of polycystic ovary syndrome
10.3760/cma.j.cn101441-20241026-00385
- VernacularTitle:肿瘤坏死因子-α对多囊卵巢综合征发病机制影响及治疗的研究进展
- Author:
Wenan LI
1
;
Yushi MENG
1
Author Information
1. 昆明医科大学第二附属医院生殖医学科，昆明 650101
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-α;
Polycystic ovary syndrome;
Oxidative stress;
Insulin resistance;
Obesity;
Gut flora;
Hyperandrogenism;
Tumor necrosis factor-α inhib
- From:
Chinese Journal of Reproduction and Contraception
2025;45(3):301-304
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS), a common reproductive, endocrine and metabolic disease among women of childbearing age, is mainly characterized by ovulation dysfunction, polycystic ovary changes and hyperandrogenism. To some extent, it impacts patients' physical and mental health. In recent years, numerous researches have indicated that the occurrence and development of PCOS are closely associated with chronic low-level inflammation in the body. Tumor necrosis factor-α (TNF-α), as an inflammatory factor, induces PCOS through different means. Accordingly, TNF-α inhibitors are also used to treat PCOS, and some patients benefit from them. However, they are off-label drugs and there are few studies. Whether TNF-α inhibitors can improve PCOS and ensure the safety of mother and child remains unclear. Therefore, this paper will review the role of TNF-α in the PCOS pathogenesis and the efficacy and safety of its inhibitors in PCOS patients, so as to offer new clues for studying the PCOS pathogenesis and new ideas for its clinical treatment.
