Randomized controlled trial on the effect of immediate addition of mifepristone after medical abortion on the complete abortion rate
10.3760/cma.j.cn101441-20241118-00424
- VernacularTitle:药物流产后即时加用米非司酮对完全流产率影响的随机对照试验
- Author:
Jun ZHU
1
;
Di WU
1
;
Yang YANG
1
;
Lirong JIANG
1
;
Chaying HE
1
Author Information
1. 杭州市妇产科医院计划生育中心，杭州 310016
- Publication Type:Journal Article
- Keywords:
Mifepristone;
Medical abortion;
Immediate addition;
Complete abortion
- From:
Chinese Journal of Reproduction and Contraception
2025;45(6):612-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical efficacy of immediately adding mifepristone tablets after medical abortion in improving the complete abortion rate.Methods:This study was a randomized controlled trial. A total of 300 patients with medical abortion in Family Planning Center of Hangzhou Women's Hospital from January 2022 to December 2023 were randomly divided into high-dose group, low-dose group and control group by the digital table method, with 100 cases in each group. The low-dose group was given mifepristone tablets 25 mg bid×5 d immediately after medical abortion; the high-dose group was given mifepristone tablets 50 mg bid×5 d immediately after medical abortion; the control did not use mifepristone after medical abortion. The complete abortion rate, the duration of vaginal bleeding, the amount of vaginal bleeding and the incidence of adverse events such as complications were compared among the three groups.Results:For the three indicators of complete abortion rate, duration of vaginal bleeding and the proportion of vaginal bleeding volume exceeding the individual's customary menstrual flow, they were 92.0% (92/100), (9.0±2.8) d and 0% respectively in the low-dose group, 89.0% (89/100), (10.8±3.0) d and 0% respectively in the high-dose group, and 67.0% (67/100), (16.5±2.6) d and 11.0% (11/100) respectively in the control. The complete abortion rate in the high-dose group and low-dose group was significantly higher than that in the control (all P<0.001), while the duration and the proportion of vaginal bleeding volume exceeding the individual's customary menstrual flow were significantly lower than those in the control (all P<0.001), and the differences were statistically significant. The incidence of complications and the occurrence level of other adverse events were similar between the high-dose and low-dose groups and the control, and the differences were not statistically significant (all P>0.05). Conclusion:Immediately giving mifepristone tablets after medical abortion can effectively improve the complete abortion rate, significantly reduce the amount and duration of vaginal bleeding in patients, and the security of the medication is good.
