Impact of different luteal phase support protocols on pregnancy outcomes in patients aged ≤35 years undergoing modified natural cycle frozen-thawed embryo transfer
10.3760/cma.j.cn101441-20240829-00317
- VernacularTitle:不同黄体支持方案对≤35岁助孕患者行改良自然周期冻融胚胎移植的孕产结局影响
- Author:
Wen ZHANG
1
;
Sheling WU
1
;
Bingnan REN
1
;
Ruolin JIA
1
;
Wenjuan ZHANG
1
;
Bijun WANG
1
;
Xiaofang DU
1
;
Yichun GUAN
1
Author Information
1. 郑州大学第三附属医院生殖健康医院，郑州 450000
- Publication Type:Journal Article
- Keywords:
Frozen-thawed embryo transfer;
Pregnancy outcome;
Luteal phase support;
Modified natural cycle frozen-thawed embryo transfer;
Perinatal outcome
- From:
Chinese Journal of Reproduction and Contraception
2025;45(3):217-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of different luteal phase support protocols on pregnancy outcomes in patients aged ≤35 years undergoing modified natural cycle frozen-thawed embryo transfer (mNC-FET).Methods:A retrospective cohort study was conducted to analyze 2 086 cycles of patients aged ≤35 years who received mNC-FET cycles in Reproductive Health Hospital of the Third Affiliated Hospital of Zhengzhou University from January 2018 to December 2020. The cycles were divided into three groups based on luteal phase support protocols used. The patients received a combination of progesterone soft capsule and dydrogesterone in the group A (446 cycles), the patients received dydrogesterone in the group B (439 cycles), and the patients received a combination of progesterone vaginal sustained-release gel and dydrogesterone in the group C (1 201 cycles). The pregnancy and perinatal outcomes were compared between groups A and B, groups C and B after matching the baseline data in a ratio of 1∶1 using the propensity score matching (PSM). The effect of different luteal phase support on live birth rate was analyzed after adjusting for confounding factors affected by univariate and multivariate generalized estimating equation (GEE).Results:After PSM, there were no significant differences between groups A and B, groups C and B in human chorionic gonadotropin positive rate, clinical pregnancy rate, ectopic pregnancy rate, live birth rate in transplant cycle, incidence of low weight, macrosomia, premature delivery rate, pregnancy complication rate and incidence of birth defects (all P>0.05). GEE analysis showed that three different luteal phase support regimens were not associated with live birth rate. Conclusion:In the mNC-FET cycle, patients aged ≤35 years who chose dydrogesterone alone as luteal phase support drug, had no difference in live birth rate and perinatal outcome between progesterone soft capsules or progesterone vaginal sustained-release gel combined with dydrogesterone, but the outcome still needs to be confirmed by large sample prospective studies.
