Research progress on the mechanism of lactic acid regulation in the decidual microenvironment
10.3760/cma.j.cn101441-20240918-00349
- VernacularTitle:乳酸调控蜕膜微环境的作用机制研究进展
- Author:
Na GAO
1
;
Zhen DOU
1
;
Xiaoli ZHAO
1
;
Tian XIA
1
Author Information
1. 天津中医药大学第一附属医院生殖医学科 国家中医针灸临床医学研究中心，天津 300381
- Publication Type:Journal Article
- Keywords:
Lactic acid;
Embryo implantation;
Lactylation;
Decidualization.
- From:
Chinese Journal of Reproduction and Contraception
2025;45(2):212-216
- CountryChina
- Language:Chinese
-
Abstract:
During decidualization, lactic acid is produced and accumulated in large amounts, becoming a prominent feature of the decidual microenvironment. Lactic acid not only serves as a key product in metabolic pathways, participating in rapid energy generation and conversion, but also influences cellular functional states by regulating the acid-base balance of the microenvironment. Furthermore, as a signaling molecule, lactic acid plays a central role in regulating decidual immune metabolism, promoting decidual angiogenesis, and facilitating trophoblast invasion, all of which are crucial for embryo implantation. In recent years, the role of lactic acid in epigenetics has also gradually emerged, with lactylation modifications involved in regulating gene expression and maintaining the homeostasis of the decidual microenvironment. This article will delve into the specific roles of lactic acid in the decidual microenvironment, aiming to provide new perspectives and theoretical foundations for the study of pregnancy-related diseases.
