Research progress of airway epithelial cell senescence mechanism in chronic obstructive pulmonary disease
- VernacularTitle:慢性阻塞性肺疾病的气道上皮细胞衰老机制研究进展
- Author:
Zhao-liang LI
1
;
Lue-li WANG
;
Qian YI
;
Ruo-qiu MA
;
Rong GUO
;
Chang-li XU
;
Xiao-hua DU
;
Wei-min YANG
Author Information
- Publication Type:Journal Article
- Keywords: chronic obstructive pulmonary disease; airway epi-thelial cells; senescence; DNA damage; epigenetic modifica-tion; chronic inflammation; oxidative stress; mitochondrial auto-phagy; senotherapy
- From: Chinese Pharmacological Bulletin 2025;41(5):805-810
- CountryChina
- Language:Chinese
- Abstract: As the first defense of respiratory system,airway epi-thelial cells(AECs)play an important role in separating the re-spiratory internal and external environment.They are essential for the natural immune function.Small airway lesions are an im-portant early pathology of chronic obstructive pulmonary disease(COPD),when AECs are exposed to harmful particles or gases for a long time,the epithelial barrier is damaged,and the signa-ling pathways which involved in differentiation,repair,and in-flammatory are disordered,resulting in epithelial cell cycle stag-nation and accelerated aging.A number of studies have sugges-ted that AECs of COPD patients express high levels of aging markers,suggesting that senescence of AECs is closely related to COPD.This review discusses the potential mechanisms of AECs senescence in COPD,the impact of AECs senescence on the de-velopment and severity of the disease,and highlights potential targets for modulating cellular senescence in airway epithelium as a therapeutic approach in COPD.
