Advances in nanomaterials for promoting bone tissue regeneration by reducing reactive oxygen species levels
10.3969/j.issn.1674-8115.2025.04.011
- VernacularTitle:纳米材料通过降低活性氧水平促进骨组织再生的研究进展
- Author:
Jiayi LU
1
;
Jinzhe LIU
;
Shangchun GUO
;
Shicong TAO
Author Information
1. 上海交通大学医学院附属第六人民医院临床医学院,上海 200233;上海交通大学医学院,上海 200025
- Publication Type:Journal Article
- Keywords:
nanomaterials;
reactive oxygen species;
bone regeneration;
antioxidant
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2025;45(4):487-492
- CountryChina
- Language:Chinese
-
Abstract:
Reactive oxygen species(ROS)are common products of bone tissue injury.If ROS cannot be removed in time,oxidative stress will be induced in the cells,which will have a negative effect on the regeneration of bone tissue.In recent years,with the deepening of research,nanomaterials capable of reducing ROS levels have shown increasing potential in promoting bone tissue regeneration.Currently,nanomaterials applied to reduce ROS levels mainly include those with surface modifications and microstructural designs,dopant-modified inorganic materials,functionalized polymeric materials and hydrogels,and nano-enzymatic materials.However,the clinical application of these nanomaterials is still limited due to their potential cytotoxicity and the lack of sufficient clinical trials.This literature review summarises the research on the use of nanomaterials to reduce ROS levels to promote bone regeneration and provides ideas for the future design and development of novel nanomaterials in this field.
