Research progress on copper death in connective tissue diseases
10.3969/j.issn.1000-484X.2025.05.043
- VernacularTitle:铜死亡在结缔组织病中的研究进展
- Author:
Ai QIAN
1
;
Yawen ZHU
;
Yuanyuan CHENG
;
Chuanbing HUANG
Author Information
1. 安徽中医药大学第一临床医学院,合肥 230038
- Publication Type:Journal Article
- Keywords:
Connective tissue disease;
Copper death;
TCA cycle;
Oxidative stress;
Inflammation
- From:
Chinese Journal of Immunology
2025;41(5):1277-1280,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Connective tissue disease(CTD)is based on chronic inflammation of blood vessels and connective tissue,often involving multiple systems.The basic pathological changes are necrotizing vasculitis,myxedema,fibrin like deformation,etc.It belongs to systemic autoimmune disease.Due to the complex pathogenesis and heterogeneity of CTD,developing personalized manage-ment strategies remains extremely challenging.Therefore,exploring the new mechanisms and treatment targets of CTD is the focus of CTD research work.In recent years,with the continuous deepening of research on CTD,it has been discovered that there is a new form of cell death in the pathological process of CTD,namely copper death.Similar to ferroptosis,copper induces cytotoxicity mediated cell death through increased mitochondrial dependent energy metabolism and accumulation of reactive oxygen species.This article mainly attempts to explore the relationship between copper death and the pathological mechanism of confirmed CTD,as well as its impact on various immune cells,as well as the opportunities and challenges faced by therapeutic targets and clinical drugs.
