Research progress on the impact of diabetes mellitus in male fertility
10.3760/cma.j.cn101441-20240717-00262
- VernacularTitle:糖尿病影响男性生育能力的研究进展
- Author:
Feixue HAN
1
;
Zhijie LI
1
;
Ziwei TAN
1
;
Zhuang WANG
1
;
Zijie CHAI
1
;
Sikai HUANG
1
;
Xiaomin LI
1
;
Geng AN
1
Author Information
1. 广州医科大学附属第三医院妇产科生殖医学中心 广东省产科重大疾病重点实验室 广东省妇产疾病临床医学研究中心 粤港澳母胎医学高校联合实验室，广州 510150
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Hyperglycemia;
Infertility, male
- From:
Chinese Journal of Reproduction and Contraception
2024;44(12):1304-1312
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus is a global epidemic characterized by high incidence and mortality rates. It can lead to both acute and chronic systemic complications. Diabetes-induced male reproductive disorders have become a focal point of concern. Numerous studies have shown that hyperglycemia can impair male fertility through various pathways, including erectile and ejaculatory dysfunction, disruption of the hypothalamic-pituitary-gonadal axis, damage to the epididymis and testis, impaired semen quality, abnormalities in testicular and sperm glucose metabolism, and adverse effects on offspring health. The mechanisms involved include oxidative stress, inflammation, autophagy, apoptosis, epigenetic regulation, and mitochondrial damage. Interventions for male fertility impairment include diabetes treatment drugs, antioxidants, Traditional Chinese Medicine and acupuncture, mesenchymal stem cell therapy, exercise and physical training, as well as gut microbiota interventions. This article aims to review the current research on the relationship between diabetes and male fertility, explore the underlying mechanisms leading to male infertility, and identify potential interventions to improve male reproductive health, which holds significant clinical value.
