Research progress in broad-spectrum monoclonal antibodies targeting surface glycoproteins of influenza A virus
10.3969/j.issn.1000-484X.2025.05.037
- VernacularTitle:靶向甲型流感病毒表面糖蛋白广谱单克隆抗体的研究进展
- Author:
Nan CHEN
1
;
Xiangjun HAO
;
Lihui CHAI
;
He XIAO
Author Information
1. 军事科学院军事医学研究院毒物药物研究所,北京 100850;河南大学抗体药物开发技术国家地方联合工程实验室,开封 475004
- Publication Type:Journal Article
- Keywords:
Influenza A virus;
Broad-spectrum;
Cross reaction;
Monoclonal antibody
- From:
Chinese Journal of Immunology
2025;41(5):1238-1245
- CountryChina
- Language:Chinese
-
Abstract:
Influenza is a major public health problem worldwide,resulting in millions of hospitalizations each year.In addi-tion to vaccination and antiviral drugs against influenza,monoclonal antibody therapy is a promising treatment method because of its cross-reactivity and targeting.Widely reactive monoclonal antibodies can bind and neutralize multiple subtypes of influenza A virus,and also show good protective effect on infected mice,showing high potential in the prevention and treatment of influenza.In this review,we briefly review the recent research progress of broad-spectrum monoclonal antibodies targeting HA and NA,two important surface glycoproteins of influenza A virus.
