Application of plant virus nanoparticles in cancer immunotherapy
10.3969/j.issn.1000-484X.2025.05.039
- VernacularTitle:植物病毒纳米颗粒在癌症免疫治疗中的应用
- Author:
Xingfu SHU
1
;
Yu ZHAO
;
Bowen ZHANG
;
Yao CHEN
;
Zhongren MA
;
Haixia ZHANG
Author Information
1. 西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室,兰州 730030;西北民族大学生命科学与工程学院,兰州 730030
- Publication Type:Journal Article
- Keywords:
Plant virus nanoparticles;
Cancer;
Immunotherapy;
In situ vaccines;
Combination therapy
- From:
Chinese Journal of Immunology
2025;41(5):1252-1256,1262
- CountryChina
- Language:Chinese
-
Abstract:
Plant virus nanoparticles(PVNPs)have inherent immune stimulation ability,which has been widely studied as an immune adjuvant to stimulate the anti-tumor immune response.PVNPs not only have the potential to be used as vaccine adjuvants for cancer immunotherapy,but also as delivery systems for single immunotherapy or combination therapies.Among them,PVNPs have achieved great success in preclinical research of cancer immunotherapy.The new immunotherapy strategy is to use PVNPs as in situ vaccination(ISV),which can effectively inhibit tumor growth and produce a widening systemic anti-tumor immune response after in-tratumoral administration;in addition,PVNPs in combination with other tumor treatment modalities may also improve the local and systemic anti-tumor immune response.In this review,the application and prospects of plant virus nanoparticles in cancer immunotherapy are reviewed,in order to provide new ideas for cancer immunotherapy.
