Mendelian randomization analysis of inflammatory bowel disease:Evidence,opportunities and challenges
10.3969/j.issn.1000-484X.2025.05.041
- VernacularTitle:炎症性肠病的孟德尔随机化分析:证据、机遇和挑战
- Author:
Jianheng HAO
1
;
Haijun WANG
;
Jia REN
;
Yuxia CAO
;
Yanlin ZHANG
;
Laixi JI
Author Information
1. 山西中医药大学第二临床学院,晋中 030619;成都中医药大学针灸推拿学院,成都 610075
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Ulcerative colitis;
Crohn's disease;
Mendelian randomization;
Genetic variation
- From:
Chinese Journal of Immunology
2025;41(5):1263-1270
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a chronic inflammatory bowel disease with a complex etiology,mainly including two types:ulcerative colitis(UC)and Crohn's disease(CD),whose risk factors for its development are still incompletely understood.In recent years,Mendelian randomization(MR)has gained increasing attention in IBD research.MR mainly uses genetic variation as an instrumental variable to infer causality between exposure and outcome,effectively avoiding confounding and reverse causality in observational studies and randomised controlled trials.This review summarises currently published MR studies related to IBD,focusing on causal relationships between different risk factors and IBD development.Current findings support a causal relation-ship between IBD and selected oral diseases,skin diseases,psychiatric disorders,autoimmune diseases,bone diseases,gut diseases,gut microbiota,cytokines and nutrients,but not between IBD and lifestyle,cardiovascular diseases and neurodegenerative diseases.Despite its limitations,MR studies are of great significance in improving understanding of etiology of IBD and in identifying potential therapeutic interventions.
