Impact of uric acid on female fertility and the pregnancy outcomes of assisted reproductive technology
10.3760/cma.j.cn101441-20241018-00380
- VernacularTitle:尿酸对女性生育力及辅助生殖助孕结局的影响
- Author:
Jun ZHANG
1
;
Shuo HUANG
;
Jing SHI
;
Qiong LIU
;
Donglin HAN
;
Xiaojun YU
;
Jie ZHAO
Author Information
1. 北京大学第三医院妇产科生殖医学中心 国家妇产疾病临床医学研究中心（北京大学第三医院）辅助生殖教育部重点实验室（北京大学）北京市生殖内分泌与辅助生殖技术重点实验室，北京 100191
- Publication Type:Journal Article
- Keywords:
Uric acid;
Hyperuricemia;
Fertility;
Reproductive techniques, assisted;
Fertilization in vitro;
Pregnancy outcome
- From:
Chinese Journal of Reproduction and Contraception
2025;45(3):305-309
- CountryChina
- Language:Chinese
-
Abstract:
Uric acid is the end product of purine metabolism in the human body. In recent years, the role of uric acid in female fertility and assisted reproductive technology (ART) has gained increasing attention. Dysregulation of uric acid metabolism can lead to hyperuricemia (HUA). HUA is not only closely related to metabolic syndrome and cardiovascular diseases but may also adversely affect female fertility by influencing ovarian function and embryos development. In this review, we explored the role of uric acid in female fertility, including its association with female subfertility, infertility, adverse pregnancy outcomes and metabolic syndrome, as well as its potential impact on ART like in vitro fertilization-embryo transfer and intracytoplasmic sperm injection. Further studies are needed to clarify the threshold and clinical intervention value of uric acid levels in women of childbearing age, providing a basis for reproductive health counseling and personalized pregnancy assistance for HUA patients of childbearing age.
