Research progress on role of necroptosis in chronic kidney disease
- VernacularTitle:坏死性凋亡在慢性肾脏病中的作用机制进展
- Author:
Ping QIU
1
;
Shuo HUANG
;
Qi-han LUO
;
Qing MA
;
Fu-zhe CHEN
;
Zi-yi SHAN
;
Yi-ming LIU
;
Chang-yu LI
Author Information
- Publication Type:Journal Article
- Keywords: necroptosis; chronic kidney disease; renal fibrosis; RIPK1; small molecule inhibitors; MLKL
- From: Chinese Pharmacological Bulletin 2025;41(5):816-820
- CountryChina
- Language:Chinese
- Abstract: Chronic kidney disease(CKD)is a chronic disease characterized by renal structural damage and dysfunction.At present,there is still a lack of effective therapeutic drugs and prevention and treatment methods for CKD in clinical practice.More and more studies have shown that necroptosis,as a new type of programmed cell death,plays a vital role in the onset and progression of CKD.Targeting key molecules in the necroptosis pathway,such as RIPK1,RIPK3 and MLKL,the development of small molecule inhibitors has become an emerging strategy for the treatment of CKD,and has shown significant potential to pro-tect the kidneys and alleviate renal fibrosis in a variety of in vitro and in vivo models.Therefore,this article summarizes the re-search progress of the mechanism of necroptosis in recent years,and focuses on the potential role of necroptosis in the pathogene-sis of CKD and the therapeutic potential of targeting this path-way,providing a new perspective and research direction for the prevention and treatment of CKD in the future.
