Efficacy of vitamin D in treating semen quality in patients with male infertility: a systematic review and meta-analysis
10.3760/cma.j.cn101441-20240531-00202
- VernacularTitle:维生素D改善男性不育患者精液质量的有效性评估：系统评价和meta分析
- Author:
Zhenwei HUANG
1
;
Jingru ZHANG
;
Dechun LI
Author Information
1. 内蒙古科技大学包头医学院，包头 014040
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Infertility, male;
Randomized controlled trials;
Meta-analysis
- From:
Chinese Journal of Reproduction and Contraception
2024;44(11):1184-1190
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the efficacy of vitamin D (VD) in the treatment of male infertility.Methods:Randomized controlled trials (RCT) on male infertility treated with VD alone or in combination were identified and collected from PubMed, Embase, Web of science, CNKI, Wanfang and VIP databases. Patients were divided into experimental group (VD or combination therapy with VD as the main treatment) and control group (placebo treatment). A meta-analysis of the included studies was performed using RevMan5.4 software. The combined effect scale was calculated as the weighted mean difference ( MD) and its 95% CI. Results:Six RCTs with a total of 673 patients were ultimately included, and the study baseline was comparable. Total sperm motility ( MD=6.49, 95% CI: 2.75-10.22, P<0.001) and percentage of forward motile sperm ( MD=5.03, 95% CI: 1.36-8.70, P=0.007) were significantly different between the experimental group and control group. Total sperm count ( MD=5.56, 95% CI: -12.62-23.75, P=0.550), sperm concentration ( MD=-0.30, 95% CI: -4.81-4.21, P=0.890), semen volume ( MD=-0.04, 95% CI: -0.18-0.09, P=0.510) and normal sperm morphology ( MD=0.42, 95% CI: -0.05-0.88, P=0.080) were not significantly different between the experimental group and control group. Conclusion:VD is effective in improving semen quality in the treatment of male infertility. However, due to the limited number of samples included in RCT, clinical trials with larger samples are still needed to further confirm this thesis.
