Impacts of immune tolerance induced by the uterine microbiota on reproductive outcomes
10.3760/cma.j.cn101441-20231106-00204
- VernacularTitle:宫腔微生物菌群诱导的免疫耐受对生殖结局的影响
- Author:
Jinwen YU
1
;
Aiyan ZHENG
1
;
Jie DING
1
;
Qingxia MENG
1
Author Information
1. 南京医科大学附属苏州医院 苏州市立医院生殖与遗传中心，苏州215002
- Publication Type:Journal Article
- Keywords:
Uterine;
Microbiota;
Immune tolerance;
Therapy;
Reproductive outcomes
- From:
Chinese Journal of Reproduction and Contraception
2024;44(8):858-861
- CountryChina
- Language:Chinese
-
Abstract:
The role of microbiota in human reproduction has become the “the second genome of humanity”. In fact, more and more researches have investigated the microbiota in reproduction, including the lower and upper reproductive tracts, and even the interactions with gametogenesis. The microbiota not only plays a crucial role in the pathological states caused by health and microecological disorders, but may also play an important role in successful fertilization and healthy pregnancy. Currently, researches on the relationship between microbiota and human reproductive axis are attracting widespread attention. This article reviews the impact of microbiota on reproductive outcomes, as well as the impact and possible mechanisms of microbiota in the uterine cavity on immune tolerance. It explores that dysbiosis of microbiota may play a role through immune tolerance. This may play a guiding role in regulating the microecology and exploring new methods for treating reproductive diseases.
