Clinical characteristics of cerebrospinal fluid in patients with central nervous system damage caused by brucellosis
10.3760/cma.j.cn231583-20231129-00122
- VernacularTitle:布鲁氏菌病中枢神经系统损害患者脑脊液临床特征分析
- Author:
Dawei CHENG
1
;
Xueying CHEN
1
;
Meinan LI
1
Author Information
1. 北大荒集团总医院感染科，哈尔滨150088
- Publication Type:Journal Article
- Keywords:
Brucellosis;
Central nervous system;
Cerebrospinal fluid
- From:
Chinese Journal of Endemiology
2025;44(3):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics of cerebrospinal fluid (CSF) in patients with central nervous system (CNS) damage caused by brucellosis and to explore its value in the clinical diagnosis of brucellosis.Methods:A retrospective analysis was conducted on medical records of patients with CNS damage due to brucellosis who were admitted to the Department of Infectious Diseases, Beidahuang Group General Hospital from December 2007 to December 2022. Epidemiological, clinical features, and CSF test results were analyzed.Results:There were a total of 50 patients with CNS damage caused by brucellosis, including 32 males and 18 females, with an age range of 18 to 72 years and a median of 45 years. All patients had a history of sheep contact. Among the 50 patients, 15 case (30.0%) had combined meningitis, 5 case (10.0%) had meningoencephalitis, 28 case (56.0%) had myelitis, 2 case (4.0%) had brain abscesses, 29 cases (58.0%) had limb motor and sensory dysfunction, 22 case (44.0%) had nausea, vomiting, and cervical stiffness, and 4 case (8.0%) experienced seizures and persistent coma. Abnormal CSF changes were observed in 48 patients, including increased intracranial pressure (> 200 mmH 2O, 1 mmH 2O = 0.009 8 kPa) in 30 cases, elevated white blood cell count in 40 cases, increased globulin levels in 47 cases, and decreased glucose and chloride levels in 38 and 40 cases, respectively. Conclusions:Patients with CNS damage caused by brucellosis exhibit diverse clinical manifestations, and abnormalities in CSF biochemical analysis are relatively commom. Epidemiological contact history and CSF analysis are of significant diagnostic value.
