Research progress on the unfolded protein response and female reproductive disorders
10.3760/cma.j.cn101441-20240420-00136
- VernacularTitle:未折叠蛋白反应与女性生殖障碍的研究进展
- Author:
Yiwen MENG
1
;
Qinling ZHU
1
;
Yun SUN
1
Author Information
1. 上海交通大学医学院附属仁济医院生殖医学中心 上海市辅助生殖与优生重点实验室，上海200135
- Publication Type:Journal Article
- Keywords:
Endoplasmic reticulum;
Mitochondria;
Unfolded protein response;
Reproductive system
- From:
Chinese Journal of Reproduction and Contraception
2024;44(10):1052-1059
- CountryChina
- Language:Chinese
-
Abstract:
The unfolded protein response is triggered by the presence of unfolded or misfolded proteins in the endoplasmic reticulum and mitochondria, aiming to regulate and maintain cellular homeostasis under stress stimuli. Recent studies have shown that unfolded protein response plays a crucial role in the pathogenesis of female reproductive-related diseases. This article delves into the specific signaling pathways of unfolded protein response in the endoplasmic reticulum and mitochondria and summarizes its impact on the physiological functions and common diseases of the female reproduction, trying to provide novel potential therapeutic targets for the diagnosis and treatment of reproductive disorder related diseases.
