Progress of ovarian tissue cryopreservation and transplantation in the fertility preservation of female childhood cancer patients
10.3760/cma.j.cn101441-20240425-00145
- VernacularTitle:卵巢组织冻存和移植在女性儿童肿瘤患者生育力保存中的研究进展
- Author:
Jinze YANG
1
;
Jianfei GONG
;
Mengmeng ZHANG
;
Jinghao YAN
;
Shen YANG
;
Xueling SONG
;
Zhiyun ZHU
;
Haiyan WANG
;
Huanmin WANG
;
Jie YAN
Author Information
1. 女性生育力促进全国重点实验室 国家妇产疾病临床医学研究中心 辅助生殖教育部重点实验室(北京大学) 北京大学第三医院妇产科生殖医学中心，北京 100191
- Publication Type:Journal Article
- Keywords:
Fertility preservation;
Ovarian tissue cryopreservation;
Ovarian tissue transplantation;
Neoplasms;
Child
- From:
Chinese Journal of Reproduction and Contraception
2024;44(10):1036-1041
- CountryChina
- Language:Chinese
-
Abstract:
With the continuous development of cancer treatment technology, the cure rate for tumors in children is increasing. However, the irreversible damage to ovarian development and function by chemotherapy and radiation in surviving children often leads to iatrogenic premature ovarian failure and even infertility. Therefore, it is of great significance to develop fertility preservation techniques for children with tumors. International and domestic guidelines indicate that ovarian tissue cryopreservation and transplantation should be considered first for female children. However, the application of this technique in children is not yet mature. Current research suggests that there are significant structural and functional differences between children's ovaries and adults', and fertility preservation strategies for adults are not fully applicable to children. Therefore, this paper analyzes and reviews the structure and function of children's ovaries, the mechanism of damage to ovarian tissues by chemotherapy and radiation, and the current research and application status of fertility preservation techniques for female children. It also looks forward to the development direction of fertility preservation techniques for female children.
