Advances in the mechanism of adhesion molecules during embryo implantation
10.3760/cma.j.cn101441-20240709-00246
- VernacularTitle:黏附分子在胚胎着床中的作用机制研究进展
- Author:
Wenzhu LI
1
;
Zhimin DENG
;
Yiqiu WEI
;
Dongyong YANG
;
Songchen CAI
;
Lingtao YANG
;
Tailang YIN
;
Lianghui DIAO
Author Information
1. 武汉大学人民医院生殖医学中心，武汉 430060
- Publication Type:Journal Article
- Keywords:
Embryo implantation;
Adhesion molecules;
Endometrial receptivity;
Embryo invasion;
Decidual immune cells
- From:
Chinese Journal of Reproduction and Contraception
2024;44(10):1098-1105
- CountryChina
- Language:Chinese
-
Abstract:
The process of embryo implantation is a multifaceted and intricate dynamic event that includes the development of endometrial receptivity, embryo localization, adhesion, and invasion. Adhesion molecules, acting as crucial mediators of communication between cells or between cells and the extracellular matrix, are essential for the maintenance of endometrial receptivity and the regulation of embryo localization, adhesion, and invasion. However, the mechanisms by which adhesion molecules of maternal and embryo are organized to regulate key events in the peri-implantation period have yet to be fully explored. Based on recent research findings, this review provides a summary of the functions of different adhesion molecules at the maternal-fetal interface and their potential regulatory mechanisms according to the key progress of embryo implantation. In particular, we discussed the interactions between decidual immune cells and other cells mediated by adhesion molecules during the invasion process, which will provide novel perspectives into the role of adhesion molecule dysfunction in contributing to implantation failure.
