Clinical study on the use of phloroglucinol combined with balloon dilation for cervical ripening
10.3760/cma.j.cn341190-20240415-00409
- VernacularTitle:间苯三酚联合宫颈扩张球囊促宫颈成熟的临床研究
- Author:
Li LIU
1
;
Dong'e LIAO
1
;
Liping LIAO
1
;
Huijuan ZHONG
1
;
Shuai LIAO
1
Author Information
1. 龙南市第一人民医院妇产科，龙南 341700
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Tissue expansion devices;
Cervix uteri;
Phloroglucinol;
Term birth;
Cervical ripening;
Pregnancy outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(10):1441-1445
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of phloroglucinol combined with ballon dilation in promoting cervical ripening and shortening labor duration in full-term primiparas and its effects on maternal and neonatal outcomes.Methods:A randomized controlled study was conducted on 60 full-term primiparas who delivered at the First People's Hospital of Longnan from January 2022 to December 2023. The subjects were randomly divided into a control group and an observation group ( n = 30/group) using the random number table method. The control group underwent ballon dilation for cervical ripening, while the observation group received intravenous injection of 80 mg phloroglucinol in addition to ballon dilation. Cervical ripening effect, labor duration, delivery mode, and the incidence of adverse pregnancy outcomes were observed in both groups. Results:The score of cervical ripening in the observation group was significantly higher than that in the control group [(8.31 ± 0.93) vs. (7.83 ± 0.85), t = 2.09, P = 0.041]. The duration of the first stage of labor, the duration of the second stage of labor, and the total duration of labor were (482.7 ± 18.2) minutes, (38.3 ± 10.7) minutes, and (526.6 ± 21.2) minutes, respectively. All these durations were significantly shorter than those in the control group [(521.3 ± 16.4) minutes, (45.7 ± 8.3) minutes, (573.4 ± 18.5) minutes, t = 2.62, 4.32, 12.80, all P<0.05]. The amount of postpartum bleeding in the observation group was significantly lower than that in the control group [(322.5 ± 21.2) mL vs. (341.9 ± 32.5) mL, t = -3.87, P<0.001]. There were no statistically significant differences in the Apgar scores and neonatal behavioral neurological assessment scores between the two groups (both P>0.05). Conclusions:The use of phloroglucinol combined with ballon dilation can effectively promote cervical ripening in full-term primiparas, shorten labor duration, improve induction success rates, and reduce postpartum hemorrhage. Therefore, this combined treatment significantly enhances maternal and neonatal outcomes while demonstrating high safety.
