Research progress and application prospects of platelet-derived mitochondrial transfer
- VernacularTitle:血小板源性线粒体转移的研究进展及应用前景
- Author:
Tian LIN
1
;
Guang-jie TAI
1
;
Ming XU
1
Author Information
- Publication Type:Journal Article
- Keywords: platelet-derived mitochondria; platelet function; mitochondrial transfer; cell communication; bioenergetics; treat-ment strategy
- From: Chinese Pharmacological Bulletin 2025;41(11):2020-2027
- CountryChina
- Language:Chinese
- Abstract: In recent years,emerging evidence has revealed the non-classical biological functions of platelets.Research on the regulation of platelet bioenergetic metabolism and its functional implications is of great significance for understanding the mecha-nisms of related diseases and developing novel therapeutic strate-gies.Current research is focusing on platelet-derived mitochon-dria because of their distinct biological characteristics.Notably,the ability of platelets to transfer mitochondria to recipient cells can reprogram the metabolism and function of these cells,poten-tially playing a pivotal role in diverse pathophysiological proces-ses.This review comprehensively summarizes the emerging roles of platelet-derived mitochondria transfer in various diseases in-cluding diabetes mellitus,cardiovascular disorders,neurodegen-erative diseases,and cancer.It further explores the application prospects in these diseases,providing a scientific basis for the development of precise therapeutic strategies.
