Preliminary study on the clinical efficacy of drug treatment combined with transcranial alternating current stimulation in the treatment of patients with bipolar I disorder
10.3760/cma.j.cn341190-20250102-00008
- VernacularTitle:药物联合tACS治疗双相Ⅰ型障碍患者临床疗效的初步研究
- Author:
Huiling WU
1
;
Long WANG
;
Shengchun JIN
;
Li WAN
;
Yaqun CHEN
;
Qinhui ZHANG
Author Information
1. 安徽医科大学精神卫生与心理科学学院，合肥 230032
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Electric stimulation therapy;
Drug therapy;
Cognitive dysfunction;
Antimanic agents
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(7):1060-1064
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of transcranial alternating current stimulation (tACS) combined with drug treatment in patients with bipolar Ⅰ disorder (BD Ⅰ).Methods:Forty-two patients with BD Ⅰ who were admitted to the Mental Health Center Affiliated to Anhui Medical University from March 2022 to June 2023 were included in this randomized double-blind study. These patients were randomly divided into a control group and an observation group using an Excel spreadsheet. In the control group, patients received 10 sessions of sham stimulation in addition to drug treatment, while the observation group received 10 sessions of tACS along with drug treatment. All patients were treated for 2 weeks. Each patient received stimulation for 15 minutes on each of the right and left prefrontal lobes once every working day. The Montreal Cognitive Assessment (MoCA) scores and Bech-Rafaelsen Mania Scale (BRMS) scores were compared between the two groups before and after treatment. Eighteen patients from the observation group and nineteen patients from the control group were included in the final analysis.Results:Two weeks after treatment, the MoCA score in the observation group was higher than that in the control group [(27.39 ± 1.88) vs. (24.63 ± 2.39)], and the BRMS score in the observation group was lower than that in the control group [(15.89 ± 3.18) vs. (19.00 ± 3.32)]. These differences were statistically significant ( t = -3.89, 2.91, both P < 0.05). After treatment, the MoCA score in the observation group increased, while the BRMS score decreased ( t = 5.04, -4.14, both P < 0.05). Pearson correlation analysis indicated the change in MoCA score was negatively correlated with BRMS score in both groups ( r = -0.433, P < 0.05). Conclusions:Drug treatment combined with tACS greatly improved clinical cognitive symptoms and reduced manic symptoms in patients with BD Ⅰ. The combined therapy exhibited better efficacy than monotherapy.
