Fertility preservation in Turner syndrome patients: challenges in ovarian tissue cryopreservation

VernacularTitle:特纳综合征女性的卵巢组织冷冻：生育力保存的挑战
Author: Fengxia LIU ¹ ; Xiaoran LI ¹
Author Information

1. 广西壮族自治区生殖医院生殖医学科，南宁　530029
Publication Type:Journal Article
Keywords: Turner syndrome; Ovarian tissue cryopreservation; Fertility preservation
From: Chinese Journal of Reproduction and Contraception 2024;44(9):959-962
CountryChina
Language:Chinese
Abstract: Turner syndrome (TS) is a common chromosomal anomaly affecting females, characterized primarily by premature ovarian failure and reduced fertility. The decline in fertility among TS patients is mainly due to abnormalities in the X chromosome, with varying degrees of ovarian reserve damage across different chromosomal karyotypes. Ovarian tissue cryopreservation has been widely used both domestically and internationally to preserve the fertility of women with TS. This article reviews the mechanisms underlying the decline in fertility in TS patients and the current application of ovarian tissue cryopreservation technology. Future efforts should focus on establishing standardized criteria for ovarian function assessment and conducting prospective studies to accurately select TS patients suitable for ovarian tissue cryopreservation, thereby optimizing outcomes for fertility preservation.