Investigation of pathophysiological mechanisms of depression based on inflammatory factors
10.3760/cma.j.cn341190-20240419-00437
- VernacularTitle:基于炎症因子探讨抑郁症的病理生理机制
- Author:
Mengli HUANG
1
;
Yun DENG
;
Yanan ZHAO
;
Lili YANG
Author Information
1. 皖北卫生职业学院病免教研室，宿州 234000
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Immunity;
Inflammation;
Tumor necrosis factor-alpha;
Interleukin-1beta;
Interleukin-6;
Toll-like receptors;
Review
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(5):796-800
- CountryChina
- Language:Chinese
-
Abstract:
Depression, one of the most prevalent mental health disorders, has emerged as a critical focus in medical and neurobiological research, as well as a major challenge for global public health. The immune-inflammatory hypothesis has been confirmed to play a pivotal role in the pathogenesis and pathophysiology of depression, though its precise mechanisms remain to be fully elucidated. This article reviews the effects of key inflammatory factors, including tumor necrosis factor-α, interleukin-1β, interleukin-6, and Toll-like receptors on depression. Additionally, it summarizes the effects of immune-inflammatory pathway invovled in the pathogenesis of depression, along with scientific clues related to inflammatory factors in this pathway. Findings from this review will provide new insights for antidepressant development and serve as a reference for evaluating the clinical efficacy of antidepressants.
