Correlation between coronary heart disease and hemoglobin levels in high-altitude regions, China
10.3760/cma.j.cn341190-20250115-00082
- VernacularTitle:高原地区冠心病与血红蛋白的相关性研究
- Author:
Xiaoshan CHEN
1
;
Kui LI
Author Information
1. 西藏大学医学院，拉萨 850000
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Angiography;
Hemoglobinometry;
Coronary artery disease;
Risk factors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(5):676-680
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between coronary heart disease and hemoglobin levels in high-altitude regions, China.Methods:This study is a single-center retrospective study involving 298 patients who were hospitalized and underwent coronary angiography at the People's Hospital of Xizang Autonomous Region from January to December 2022. The patients were divided into a lesion group and a control group based on the presence of coronary artery lesions. Among them, 152 patients were diagnosed with coronary heart disease and were assigned to the lesion group, while 146 patients had normal coronary angiography results and were included in the control group. Hemoglobin levels, age, systolic blood pressure, diastolic blood pressure, and other relevant data were compared between the two groups. Furthermore, based on the status of the coronary artery lesions, the patients were categorized into single-vessel lesion, double-vessel lesion, and triple-vessel lesion groups to analyze the correlation between the Gensini score for coronary artery disease and hemoglobin levels in each group.Results:In the control group, hemoglobin, age, D-dimer, fibrinogen degradation products, glycated hemoglobin, C-reactive protein, and fibrinogen were (182.52 ± 28.45) g/L, (59.84 ± 13.14) years, (0.62 ± 1.70) mg/L, (2.92 ± 7.41) mg/L, (6.20 ± 1.22)%, (8.46 ± 21.90) mg/L, and (3.59 ± 1.87) g/L, respectively. In the lesion group, these values were (156.53 ± 23.35) g/L, (56.72 ± 12.70) years, (1.42 ± 2.69) mg/L, (5.32 ± 9.93) mg/L, (6.85 ± 1.88)%, (44.56 ± 64.29) mg/L, and (4.48 ± 2.18) g/L, respectively. The lesion group had lower hemoglobin levels and younger age, while levels of D-dimer, fibrinogen degradation products, glycated hemoglobin, C-reactive protein, and fibrinogen were significantly higher ( t = -5.58, -8.75, -2.59, -2.00, -2.82, -5.29, -3.21, all P < 0.05). A binary logistic regression analysis of these factors revealed that hemoglobin ( OR = 0.35, 95% CI: 0.08-0.78) is a protective factor for coronary heart disease ( P < 0.05). Both D-dimer ( OR = 1.42, 95% CI: 1.00-2.15) and glycated hemoglobin ( OR = 1.30, 95% CI: 1.00-1.60) were identified as independent risk factors for coronary heart disease (both P < 0.05). In the lesion group, hemoglobin levels were highest in the single-vessel lesion group [(161.22 ± 19.28) g/L], followed by the double-vessel lesion group [(154.84 ± 23.66) g/L], and lowest in the triple-vessel lesion group [(144.34 ± 26.57) g/L, all P < 0.05]. The Gensini scores were highest in the triple-vessel lesion group (89.96 ± 33.14), followed by the double-vessel lesion group (59.25 ± 17.28), and lowest in the single-vessel lesion subgroup (8.35 ± 4.56) (all P < 0.05). Conclusions:Hemoglobin is a protective factor for coronary heart disease, with lower hemoglobin levels associated with more severe coronary artery lesions in coronary heart disease.
