Research progress of biological functions of miR-101-3p in cardiovascular diseases
- VernacularTitle:miR-101-3p的生物学功能及其在心血管疾病中的研究进展
- Author:
Zhihua PANG
1
;
Limei LIU
;
Zhuhua YAO
Author Information
- Publication Type:Journal Article
- Keywords: myocardial infarction; heart failure; atherosclerosis; miR-101-3p; myocardial fibrosis
- From: Tianjin Medical Journal 2025;53(11):1223-1227
- CountryChina
- Language:Chinese
- Abstract: miR-101-3p is an evolutionarily conserved non-coding RNA that has shown aberrant expression and regulatory functios in various cardiovascular diseases(CVDs)in recent years.It participates in key pathological processes including post-infarction myocardial remodeling,myocardial fibrosis in heart failure and the development of atherosclerosis by modulating pathways such as apoptosis,autophagy and metabolism.In addition,it exhibits immunoregulatory potential in myocardium injury related to systemic diseases.This review summarizes the recent advances in understanding the role of miR-101-3p in CVDs,focusing on its expression dynamics and regulatory mechanisms in different disease models.It further elaborates on the biological effects of miR-101-3p in cardiovascular pathology and explores its potential as a diagnostic biomarker and therapeutic target.miR-101-3p is expected to provide novel insights for early detection and targeted intervention of cardiovascular diseases.
