Research progress of endometrial receptivity defects in patients with PCOS
10.3760/cma.j.cn101441-20240310-00089
- VernacularTitle:PCOS患者子宫内膜容受性缺陷研究进展
- Author:
Jiayuan CHEN
1
;
Tianxiang NI
1
;
Junhao YAN
1
Author Information
1. 山东大学妇儿与生殖健康研究院 山东大学国家辅助生殖与优生工程技术研究中心 山东省生殖健康临床医学研究中心，济南 250012
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Endometrial receptivity;
Metabolism;
Genome-wide association study
- From:
Chinese Journal of Reproduction and Contraception
2024;44(10):1021-1026
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a reproductive endocrine disorder that is more common in women of childbearing age, which seriously affects women's quality of life and fertility, taking a toll on both physical and mental health as well as economic capacity. At present, the problems of thin ovulation and endocrine disorders in PCOS patients can be corrected by fertility drugs, but the endometrial receptivity of the patients is still in a poor state, and there is still a situation of inability to conceive. Current studies have shown that endometrial receptivity defects in PCOS patients are closely related to abnormal expression of metabolism, immunity, hormones and their receptors, etc. However, the specific pathological mechanism and etiology have not been fully clarified. This paper mainly discusses the factors of endometrial receptivity defects in patients with PCOS, and focuses on three aspects: genetic and epigenetic abnormalities, metabolic abnormalities, and immune disorders, trying to provide some clues for future treatment options and new drug targets for PCOS patients.
