A multicentre cross-sectional study on the correlation of female sexual dysfunction with sex hormones
10.3760/cma.j.cn101441-20230630-00256
- VernacularTitle:女性性功能障碍与性激素相关性的多中心横断面研究
- Author:
Rui JU
1
;
Xiangyan RUAN
;
Yinmei DAI
;
Yu YANG
;
Xin XU
;
Jiaojiao CHENG
;
Yongtao BAI
;
Yanhong SHI
;
Xingzi YANG
;
Yanhua SUN
;
Ruiling LI
;
Mueck Alfred O.
Author Information
1. 首都医科大学附属北京妇产医院 北京妇幼保健院药物临床试验机构办公室，北京 100026
- Publication Type:Journal Article
- Keywords:
Menopause;
Sex hormones;
Female sexual dysfunction;
Sexual function index;
Staging of reproductive aging
- From:
Chinese Journal of Reproduction and Contraception
2024;44(3):278-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between endogenous sex hormone factors and sexual function in Chinese women.Methods:A total of 711 women who met the criteria were investigated in the Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Chaoyang District Maternal and Child Health Care Hospital, Beijing Chaoyang District Taiyanggong Community Health Service Centre from April 2020 to March 2021. Sociodemographic data (data split into two groups according to educational background: high school or above and lower high school; and three categories based on marital relationship: satisfied, average, and dissatisfied) and serum levels of sex hormones were collected. Female sexual dysfunction (FSD) was evaluated using the female sexual function index (FSFI). Participants were divided into three groups according to the Stages of Reproductive Aging Workshop (STRAW+10): reproductive stage group, menopausal transition stage group and postmenopausal stage group. Spearman rank correlation analysis and multiple linear regression analyses were performed to determine the correlation between characteristics and scores of FSFI.Results:The multivariate logistic regression analysis revealed that postmenopausal stage, secondary education level, neutral and dissatisfied marital relations were significantly negatively correlated with total FSFI score (all P<0.01). Secondary education level, neutral and dissatisfied marital relations were negatively associated with nearly all FSFI domains apart from pain score (all P<0.05); postmenopausal stage was negatively associated with lubrication, satisfaction and pain (all P<0.05). FSH was negatively associated with all FSFI domain scores (all P<0.05). There was a significantly positive correlation between estradiol and scores of FSFI dimensions other than orgasm and satisfaction (all P<0.05). Total testosterone positively affected the score of total FSFI and desire (all P<0.05); free testosterone was positively related to orgasm ( P<0.05). Conclusion:Estradiol and total testosterone serve as protective factors for female sexual function.
