Advances research of gonadotropin-releasing hormone agonist in the protection of ovarian function in young breast cancer patients undergoing chemotherapy
10.3760/cma.j.cn101441-20231009-00152
- VernacularTitle:促性腺激素释放激素激动剂在年轻乳腺癌化疗患者卵巢功能保护中的研究进展
- Author:
Luyao WANG
1
;
Yifan CHU
1
;
Jiaxin XIE
1
;
Shulin YANG
1
;
Liu YANG
1
;
Lei JIN
1
;
Jing YUE
1
Author Information
1. 华中科技大学同济医学院附属同济医院生殖医学中心，武汉 430030
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Chemotherapy;
Fertility preservation;
Gonadotropin-releasing hormone agonist
- From:
Chinese Journal of Reproduction and Contraception
2024;44(8):853-857
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of breast cancer is on the rise annually, and chemotherapy is potentially effective in prolonging the lifespan of young breast cancer patients which also irreversibly harm the ovaries. Recently, increasingly more studies have focused on the role of gonadotropin-releasing hormone agonist (GnRH-a) for protecting ovarian function in patients undergoing chemotherapy with disputable findings. This review addresses four perspectives including the impact of chemotherapy on ovarian function, the introduction of GnRH-a and the possible mechanism of protecting ovarian function, the advances of clinical research on the ovarian protection by GnRH-a in chemotherapy for patients with breast cancer and other related issues, with the aim of providing thoughts for clinical diagnosis and associated research.
