Research progress of PARP inhibitors in the treatment of brain glioma

VernacularTitle:PARP抑制剂在脑胶质瘤治疗中的研究进展
Author: Cong SONG ¹ ; Jinglin GAO ; Feng BAN ; Meng MENG ; Mingxia WANG
Author Information

1. 河北医科大学第四医院临床药理研究部;河北医科大学第四医院药学部
Publication Type:Journal Article
Keywords: PARP inhibitors; brain glioma; mecha-nism of action; blood-brain barrier permeability
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2025;30(9):1281-1289
CountryChina
Language:Chinese
Abstract: Poly-(adenosine diphosphate-ribose)-polymerase(PARP)inhibitors are a novel group of small molecule targeted therapeutic drugs.It has become an effective treatment for ovarian cancer,prostate cancer and breast cancer carrying BRCA1/2 mutations.Studies have demonstrated that PARP inhibitors(PARPi)can improve treatment outcomes by targeting genetic defects in tumors with syner-gistic effects with standard therapies for glioma treatment,such as increasing radiation sensitivity and overcoming temozolomide resistance.Howev-er,the limited blood-brain barrier permeability,the adverse reactions of drug combination and the oc-currence of drug resistance are the key factors af-fecting the therapeutic effect.This article reviews the mechanism of action and research progress of PARP inhibitors involved in the treatment of brain glioma,and analyzes the challenges to be faced in clinical practice,in order to provide references for future research in this field.