Research progress on the interaction between epithelial cells and macrophages in lung diseases
10.12092/j.issn.1009-2501.2025.09.012
- VernacularTitle:上皮细胞和巨噬细胞相互作用在肺部疾病中的研究进展
- Author:
Mengyu LI
1
;
Wei JIANG
;
Yafei ZHANG
;
Xin PAN
;
Yuanyuan WANG
Author Information
1. 安徽医科大学药学院,合肥 230032,安徽;安徽医科大学第二附属医院药学部,合肥 230601,安徽
- Publication Type:Journal Article
- Keywords:
epithelial cell;
macrophage;
interac-tion;
idiopathic pulmonary fibrosis;
chronic obstruc-tive pulmonary disease;
lung cancer
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(9):1253-1259
- CountryChina
- Language:Chinese
-
Abstract:
The interaction between epithelial cells and macrophages plays a crucial role in the progression of lung diseases,including immune de-fense,inflammation regulation,tissue repair,and regeneration.However,an imbalance in this inter-action can contribute to the development of vari-ous lung diseases.In idiopathic pulmonary fibrosis,chronic obstructive pulmonary disease,and lung cancer,macrophages can promote disease progres-sion by secreting cytokines that act on epithelial cells.Simultaneously,activated epithelial cells re-lease cytokines to recruit and activate more macro-phages in a positive feedback loop.Thus,compre-hensive studies of the interactions between epithe-lial cells and macrophages in various lung diseases have the potential to identify new therapeutic tar-gets and develop innovative strategies for disease management.This review aims to summarize the current knowledge regarding the interaction be-tween epithelial cells and macrophages in idiopath-ic pulmonary fibrosis,chronic obstructive pulmo-nary disease,and lung cancer,with the goal of in-spiring new research directions for the treatment of lung diseases.
