Apelin:A new target for the prevention and treatment of chronic kid-ney disease
10.12092/j.issn.1009-2501.2025.09.011
- VernacularTitle:Apelin:慢性肾脏疾病防治的新靶点
- Author:
Chengguo LYU
1
;
Caiqian WU
;
Qianrui MI
;
Guojing ZHANG
;
Ling LI
;
Qifa YE
Author Information
1. 武汉大学中南医院,武汉大学肝胆疾病研究院,武汉大学移植医学中心,国家人体捐献器官获取质量控制中心,移植医学技术湖北省重点实验室,武汉 430071,湖北
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
Apelin;
dia-betic nephropathy;
immune-associated nephropa-thy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(9):1243-1252
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease(CKD)is a chronic renal structural and functional disorder caused by multiple causes(history of kidney injury>3 months),with complex etiology and high inci-dence,which will eventually lead to end-stage re-nal disease(ESRD).Common chronic kidney diseas-es include diabetic nephropathy,polycystic ne-phropathy,nephrogenic diabetes insipidus and re-nal fibrosis.At present,there is still a lack of effec-tive specific treatment for chronic kidney disease.The Apelin system is an endogenous physiological regulator.Studies have shown that Apelin is in-volved in the occurrence and development of the above diseases mainly through the regulation of kidney body fluids and blood vessels,and the regu-lation of kidney glucose and lipid metabolism and immunity.This article aims to review the role of Apelin in chronic kidney diseases in recent years,and provide ideas for the treatment and drug de-velopment of kidney diseases with Apelin as a new target.
