Research progress on cuproptosis inducers overcoming tumor multidrug resistance
- VernacularTitle:具有克服肿瘤多药耐药性的铜死亡诱导剂的研究进展
- Author:
Sha-sha LUO
1
;
Qin-you TAN
Author Information
- Publication Type:Journal Article
- Keywords: MDR; drug resistance mechanisms; copper iono-phores; copper complexes; cuproptosis; anti-tumor
- From: Chinese Pharmacological Bulletin 2025;41(11):2032-2037
- CountryChina
- Language:Chinese
- Abstract: In recent years,cancer incidence has been rising.Chemotherapy is a key clinical treatment,yet long-term use of antitumor drugs can lead to multidrug resistance(MDR).This review introduces the causes and mechanisms of MDR,mainly including genomic mutations,cellular autophagy,tumor micro-environment,and apoptosis.Subsequently,the concept and mo-lecular mechanisms of Cuproptosis are introduced,pointing out that the abnormal accumulation of Cu2+in cells and the chain reaction triggered by the binding of excess Cu2+with mitochon-drial enzymes ultimately lead to cell death.Finally,copper ionophores,copper complexes as drugs,and strategies for indu-cing cuproptosis to reverse drug resistance are introduced.The prospects for exploring antitumor drugs that can reverse MDR are briefly discussed,bringing new ideas to overcoming tumor resist-ance.
