Role of Sirtuins family proteins in ovarian aging
10.3760/cma.j.cn101441-20230420-00164
- VernacularTitle:Sirtuins家族蛋白在卵巢衰老过程中的作用
- Author:
Jing WANG
1
;
Huiru CHENG
1
;
Zhiguo ZHANG
1
;
Yunxia CAO
1
Author Information
1. 安徽医科大学第一附属医院妇产科 国家卫生健康委配子及生殖道异常研究重点实验室 生殖健康与遗传安徽省重点实验室，合肥 230032
- Publication Type:Journal Article
- Keywords:
Sirtuins;
Nicotinamide adenine dinucleotide;
Oxidative stress;
Chromosome segregation;
Genomic stability;
Ovarian aging
- From:
Chinese Journal of Reproduction and Contraception
2024;44(7):759-763
- CountryChina
- Language:Chinese
-
Abstract:
The decline of ovarian function due to aging is an irreversible natural physiological process, manifested by the progressive depletion of follicles and the decrease of oocyte quality in the ovary. Existing studies have shown that the Sirtuins family is involved in the development of ovarian aging through various pathways, such as regulation of nicotinamide adenine dinucleotide levels, oxidative stress, chromosome segregation and genomic stability. In this paper, we review the current roles of Sirtuins family proteins in ovarian aging and their molecular mechanisms.
