Research progress on biological factors in bipolar disorder comorbid with eating disorders
10.3969/j.issn.1002-0152.2025.08.010
- VernacularTitle:双相障碍共病进食障碍的神经生物学因素研究进展
- Author:
Jinping ZHUO
1
;
Yiliang ZHANG
1
;
Abula MUNILA
1
;
Linna CHU
1
;
Shuming ZHONG
1
;
Yanbin JIA
1
Author Information
1. 暨南大学附属第一医院精神医学科(广州 510630)
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Eating disorders;
Binge eating;
Anorexia nervosa;
Bulimia nervosa;
Comorbidity;
Genetic polymorphism;
Neuroimaging
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(8):501-506
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of comorbidity of eating disorders(ED)and bipolar disorder(BD)is high,and patients with comorbid conditions often have a high risk of suicide and poor prognosis.Exploring the pathogenesis of BD comorbid with ED is of great significance for improving clinical efficacy and adverse prognosis in patients.The mechanisms underlying BD comorbid ED remain unclear,involving multifaceted neurobiological factors such as serotonin system dysfunction,dopamine reward pathway disruption,abnormal immune system activation,fluctuations in sex hormone levels,and functional and structural abnormalities in brain regions associated with emotional control and reward system pathways.Therefore,this article provides ideas for the research direction of BD comorbid with ED by analyzing the roles of genetic metabolism,neurobiochemistry,immune,and imaging changes in the comorbidity mechanism.
