Advancements of proteomic techniques in research on common mental disorders diagnosis and treatment
10.3969/j.issn.1002-0152.2025.08.009
- VernacularTitle:蛋白质组学技术在常见精神疾病诊治研究中的进展
- Author:
Yuyan LIN
1
;
Zhen WANG
1
Author Information
1. 上海交通大学医学院附属精神卫生中心(上海 200030)
- Publication Type:Journal Article
- Keywords:
Proteomics;
Psychiatric disorders;
Schizophrenia;
Depressive disorder;
Alzheimer disease;
Bio?markers;
Diagnosis;
Therapeutic targets
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(8):496-500
- CountryChina
- Language:Chinese
-
Abstract:
Clinical diagnosis and treatment of psychiatric disorders still rely primarily on subjective symptom assessment,leading to difficulties in early identification,a lack of objective biomarkers,and insufficient monitoring of treatment efficacy.Proteomics is a field that investigates protein structure,function,interactions,and their alterations under physiological or pathological conditions.In recent years,proteomic technologies have achieved significant advances in psychiatric research:In schizophrenia studies,proteomics has uncovered abnormalities in energy metabolism,immune responses,and lipid metabolism,with some differentially expressed proteins serving as potential biomarkers and therapeutic targets;In depressive disorders,proteins associated with inflammatory responses,oxidative stress,and mitochondrial dysfunction have been closely linked to disease mechanisms,and multi-marker panels show promise in improving diagnostic accuracy and monitoring treatment response;In Alzheimer disease research,the detection of Aβ,tau,and related signaling pathway proteins has facilitated early screening and the development of targeted therapies.
