Research progress on bone microenvironment-mediated drug resistance in breast cancer bone metastasis
10.11904/j.issn.1002-3070.2025.05.014
- VernacularTitle:骨微环境介导乳腺癌骨转移耐药性的研究进展
- Author:
Rui LYU
1
;
Linlin ZHEN
1
Author Information
1. 南京医科大学附属淮安第一医院甲乳外科(淮安 223300)
- Publication Type:Journal Article
- Keywords:
bone metastasis;
drug resistance;
preclinical model;
drug delivery systems
- From:
Practical Oncology Journal
2025;39(5):450-456
- CountryChina
- Language:Chinese
-
Abstract:
In comparison with other malignancies,the diagnosis and treatment of primary breast cancer are relatively mature.However,the clinical management of breast cancer bone metastasis primarily relies on drugs,but this approach struggles to completely eliminate tumor cells and is often accompanied by drug resistance,leading to osteolytic destruction and aggressive tumor proliferation,severely compromising patients' quality of life and survival.Previous studies have focused primarily on breast cancer cells themselves,with less attention paid to how they exploit the protective mechanisms of the bone microenvironment to resist drug therapy.The study reviews the relevant literature to explore the role of the bone microenvironment in the development of drug resistance in breast cancer bone metastasis,hoping to provide new insights into the treatment of breast cancer bone metastasis.
