Lactylation modification:an emerging target in cancer therapy
10.11904/j.issn.1002-3070.2025.05.011
- VernacularTitle:乳酸化修饰:癌症治疗中的新兴靶点
- Author:
Xin XIN
1
;
Wenjing XIONG
;
Chunnuan ZHANG
;
Xiaojing LI
;
Xue GAO
;
Yue ZHANG
Author Information
1. 哈尔滨医科大学附属肿瘤医院肿瘤内科(哈尔滨 150081)
- Publication Type:Journal Article
- Keywords:
post-translational modification;
lactylation;
cancer;
tumor microenvironment
- From:
Practical Oncology Journal
2025;39(5):433-436
- CountryChina
- Language:Chinese
-
Abstract:
Post-translational modification of protein is a key mechanism for regulating cancer development and immune re-sponses,and has become an important target for cancer diagnosis and treatment.Among them,lactylation modification provides a new perspective for the precise prevention and control of tumors by affecting metabolism and epigenetics.Lactylation modification precisely regulates the functions of histone and non-histone,affecting tumor cell characteristics,microenvironment acidification,and immune cell functions,becoming a key hub connecting metabolic reprogramming and malignant phenotypes.This article reviews the regulatory roles of lactylation modification in tumor development,immune escape,clinical translation,and explores the potential of targeted inhi-bition of lactylation modification and its related pathways,as well as the inhibition of key enzyme activity.
